In this case it turned out to be due to some errors that were occurring at the network level. In order to determine if your environment is seeing this particular problem, take a network capture using Netmon 3.1.
Apply a Display filter.
smb.DOSError.Error != 0 || smb.NTStatus.Code != 0
You will see errors that look like the following which are really not errors, but just indicate that the RL is polling the network share.
14:40:49.660 61777 180.189804 {SMB:2897, NbtSS:6, TCP:5, IPv4:4} 172.20.10.2 172.20.12.60 SMB SMB:R; Transact2, Find First2 - NT Status: System - Error, Code = (15) STATUS_NO_SUCH_FILE
However, if the following errors occur, there is a problem, and the receive location will be disabled. You will see these in succession in the capture with the above filter. In this case the errors continued to occur even after the receive location was moved to a UNC that was not a part of the Distributed File System Share.
14:40:50.613 61992 181.142929 {SMB:2910, NbtSS:6, TCP:5, IPv4:4} 172.20.10.2 172.20.12.60 SMB SMB:R; Transact2, Query Path Info - NT Status: System - Error, Code = (860) STATUS_NETWORK_SESSION_EXPIRED
14:40:50.613 62008 181.142929 {SMB:2913, NbtSS:6, TCP:5, IPv4:4} 172.20.10.2 172.20.12.60 SMB SMB:R; Transact2, Query Path Info - NT Status: System - Error, Code = (58) STATUS_OBJECT_PATH_NOT_FOUND
14:40:50.613 62013 181.142929 {NbtSS:6, TCP:5, IPv4:4} 172.20.10.2 172.20.12.60 SMB SMB:R; Nt Transact, Unknown NT Transaction Function - NT Status: System - Error, Code = (288) STATUS_CANCELLED
14:40:50.613 62008 181.142929 {SMB:2913, NbtSS:6, TCP:5, IPv4:4} 172.20.10.2 172.20.12.60 SMB SMB:R; Transact2, Query Path Info - NT Status: System - Error, Code = (58) STATUS_OBJECT_PATH_NOT_FOUND
14:40:50.613 62013 181.142929 {NbtSS:6, TCP:5, IPv4:4} 172.20.10.2 172.20.12.60 SMB SMB:R; Nt Transact, Unknown NT Transaction Function - NT Status: System - Error, Code = (288) STATUS_CANCELLED
This fix is for the redirector. To resolve the error, apply this fix on each Biztalk Server.